Dr. Keith has a great depth of experience in Comparative Medicine-Animal Models of Human Disease, as well as preclinical study design, review of experimental data, analysis and documentation of animal model studies, scientific report preparation, and manuscript preparation and editing. He is author or co-author of over 140 peer-reviewed papers and book chapters, an invited reviewer for multiple national and international scientific journals, and an inventor or co-inventor on 31 issued US and International patents.
Dr. Keith most recently worked at Genetics Institute / Wyeth Research / Pfizer, and achieved the title of Distinguished Research Fellow (2006 – 2011), after starting his career with them as a Senior Principal Scientist and Lab Head of the Animal Models Laboratory in Preclinical Research. His laboratories conducted animal model studies defining biologic activities, biomarkers of efficacy and safety, and minimum effective doses of cardiovascular, inflammatory disease drug candidate molecules, recombinant human cytokines, and recombinant human therapeutic proteins for hemophilia. The pharmacology research and development contributed to the approval of Neumega, BeneFIX, ReFacto (Europe), ReFacto (US), and Xyntha. Prior to entering the pharmaceutical industry, Dr. Keith served 11 years as an Assistant and Associate Professor of Veterinary Medicine at the Virginia-Maryland Regional College of Veterinary Medicine. It was there that the research on atherosclerosis continued and the new area of interest concerning the pathophysiology of preeclampsia emerged.
Dr. Keith earned his PhD at the University of Georgia in Physiology and Pharmacology for his work concerning the response to injury hypothesis of atherogenesis and low-dose aspirin therapy for prevention or regression of vascular injury-induced arteriosclerosis. He received both his D.V.M. and B.S. degree from the University of Tennessee in Knoxville. He is a member of numerous professional organizations, including the American Heart Association, the American Physiological Society, the American Veterinary Medical Association, the Shock Society, the New York Academy of Sciences, the Royal Society of Medicine (London)-Fellow, and the International Society for the Study of Hypertension in Pregnancy.